With the MicroRobot 50 microdosing machine, Romaco Macofar offers an innovative high-tech solution for filling cytostatic powders into injection vials. Three anthropomorphic robots ensure safe processes under isolator protection.
The robotic Microdosing machine MicroRobot 50 from Romaco Macofar was specially developed for the filling of highly potent and cytostatic drugs used, for example, in the treatment of cancer and autoimmune diseases.
The technology is particularly suitable for Dosing of irregularly shaped, sticky and hygroscopic pharmaceutical powders. Filling of sterile liquids is also possible. The Macofar MicroRobot 50 is available with isolator technology for high-containment applications up to OEB level 5. Alternatively, a version with cRABS or oRABS for non-cytotoxic products is also possible.
Robots work format-free
Transport during production three anthropomorphic robots the vials under the isolator to the dosing, stoppering and crimping stations. The robots work format-free, which significantly reduces product changeover times.
In total the robotic transfer system reduces the particle concentration in the critical areas and thus reduces the risk of contamination. In addition, the MicroRobot 50 microdispensing machine is easily accessible and easy to clean thanks to a tidy system concept. To validate the cleaning processes, the manufacturer equips the robotic grippers with optional cleaning guns.
Overall, the Macofar MicroRobot 50 achieves a Maximum output of 50 vials per minute including one hundred per cent in-process weight control. This means that each vial is weighed individually before and after filling. If necessary, the filling volume is automatically adjusted.
Micro-dosing machine reduces product loss to a minimum
Numerous control systems ensure that reliable process and a very low reject rate of high-priced medicines. If a stopper is missing, for example, the filled vial is not rejected but returned to the relevant station, where the process is then repeated. The same measure is also taken if a crimp cap is missing. To prevent the product loss to a minimum overall, the dosing station of the microdosing machine is designed in such a way that the remaining quantity of the batch is always less than 100 grams.
The very compact system with a length of less than four metres was designed with ergonomic aspects in mind. All parts that come into contact with the product are extremely small and light. Care was also taken to ensure that the Components easy to remove and install are. The machine is accessed via glove ports and RTP systems. The isolator is equipped with an integrated VHP generator for bio-decontamination.
The MicroRobot 50 combines the expertise of Romaco Macofar in powder filling with the Insulator technology from Truking. The robotic microdosing machine is the first joint development project of the two pharmaceutical machinery specialists from Italy and China. The results are very positive: two pharmaceutical manufacturers from Asia have already ordered the MicroRobot 50.
Source: Romaco Group
