Syntegon Technolgy presents the new GKF 60 capsule filling machine, which has been specially developed for laboratories and research-based pharmaceutical companies and offers dosing flexibility in the smallest of spaces.
„Researching pharmacists and laboratories need to bring their new drugs to market quickly and in a targeted manner. Authorisation bring. To do this, they need a mobile plant that enables the development of new formulations with the different dosing systems flexible and under different OEB levels possible. But that's not all: the systems used should also be easy to scale up to production,“ explains Matthias Mössinger, Senior Market Expert Pharma Solid at Syntegon, describes the new development.
High flexibility and low space requirements
With just six stations, the GKF 60 is extremely compact. „Nevertheless, a total of three filling stations can be integrated in parallel. Customers can choose from numerous options - from the newly developed piezo dosing system to the familiar dosing modules for dry powder inhalation (DPI), pellets, tablets or liquids, through to the mini-bowl station for scaling up to the next larger production machine,“ explains Mössinger. This is particularly important for very high-priced active ingredients, small quantities flexibly and with as little product loss as possible filling. This is possible on the piezo station of the GKF 60 even for very small quantities from 0.1 milligram filling weight, for example for carrying out toxicity or first-in-man (FIM) studies.
Syntegon's newly developed Automated Process Development (APD) tool is used to determine the optimum parameters for filling and automatically adjust them during the filling process. In addition, each dosing station can be optionally equipped with gravimetric 100 per cent weighing for each dosed component. „With these and numerous other options, such as cameras and sensors, the new capsule filling machine provides the necessary control during the running process. Quality control and guarantees the highest product quality,“ says Mössinger.
From OEB3 to High Containment
Customers can choose the GKF 60 either in the standard version, the containment version or a combined solution. With the newly developed Switching concept the capsule filling machine offers maximum flexibility. „Thanks to interchangeable cabin elements and a sophisticated cleaning concept, including WIP (washing in place), the combi-solution can be adapted for both simple and highly potent formulations up to OEB5 High-Containment in just a few simple steps,“ says Mössinger. Another novelty: „Thanks to the identical basic machine design, the standard version can be easily retrofitted.
The separate control cabinet with integrated operator interface and particularly user-friendly dashboard saves even more space. „The GKF 60 is a future-proof machine that can be further develop in the direction of automation and Industry 4.0 will be,“ emphasises Mössinger. As the new capsule filling machine is also compatible with the GKF 720, Syntegon's smallest production-scale capsule filling machine, nothing stands in the way of scaling up newly developed formulations.
Syntegon will be presenting the GKF 60 at the virtual Achema Pulse on 15 and 16 June 2021. The capsule filling machine will also be available for customer presentations at the new OSD Customer Centre in Waiblingen.
Source: Syntegon
